![]() Expression of MSC markers was also detected at the surface of native, noncultured perivascular cells. ![]() Irrespective of their tissue origin, long-term cultured perivascular cells retained myogenicity exhibited at the clonal level osteogenic, chondrogenic, and adipogenic potentials expressed MSC markers and migrated in a culture model of chemotaxis. Perivascular cells purified from skeletal muscle or nonmuscle tissues were myogenic in culture and in vivo. We have prospectively identified perivascular cells, principally pericytes, in multiple human organs including skeletal muscle, pancreas, adipose tissue, and placenta, on CD146, NG2, and PDGF-Rβ expression and absence of hematopoietic, endothelial, and myogenic cell markers. ![]() Mesenchymal stem cells (MSCs), the archetypal multipotent progenitor cells derived in cultures of developed organs, are of unknown identity and native distribution.
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